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The possibility of utilizing the body’s own natural defenses to seek and destroy primary tumors has attracted researchers for over one hundred years. Only in the current era of molecular and cellular biology has it been possible to demonstrate efficacy of various immunotherapies in a double blind, placebo controlled manner. With the staggering deluge of clinical and basic research information accumulating regarding the complex interplay between tumors and the immune system, it is very easy for researchers to lose track of important developments in the field.
The purpose of this book is to provide a broad overview of tumor immunology, and in some places to dive deeply into therapies and combination therapies that may have utility the current day practice of cancer immunotherapy. The book was written with the objective of bringing to light various findings that have been somewhat ignored by mainstream researchers, and to propose how these findings may synergize with the current immunotherapeutic protocols that are in the clinical or being in late phases of clinical development.